Reduced Heart Rate Response during Drug-Induced Stress Is Related to the Severity of Perfusion Defect

Introduction: During the pharmacological stress test with dipyridamole, a normal hemodynamic response is slightly reduced blood pressure and raised heart rate (HR). However, sometimes HR reduced. This study investigated relationship between during dipyridamole severity of perfusion defects using Thallium 201 myocardial imaging. Methods: We enrolled 50 patients undergoing at nuclear cardiology Lab, Main University Hospital of Alexandria. Standard protocol (infusion over 4 min) and standard thallium (2 min after infusion) were followed. If (HR) ratio (peak HR/rest HR) was 1.20 or less, it considered response. Total defect (TPD), summed score (SSS), rest (SRS), difference (SDS) for perfusion were calculated. Patients responses compared independent predictors determined. Results: About 56% had response; which included high number history dyslipidemia diabetes mellitus. The group showed lower SSS, SRS. analysis that HR, Conclusions: Reduction in dipyridamole-induced related to defect, mellitus, Dyslipidemia.